In Vivo Pharmacology
Unlock translational insights with our tailored in vivo preclinical pharmacology solutions
Our In Vivo Pharmacology platform provides research teams with preclinical experimental services designed to deliver critical in vivo insights into mRNA formulation performance. With extensive preclinical expertise and end-to-end support, we help streamline your research and accelerate your path to discovery.
Platform Capabilities:
Access to Different Mouse Models
Access widely used mouse strains (e.g., BALB/c, C57BL/6J), with additional models potentially available upon request.
mRNA-LNP Biodistribution and Pharmacokinetics Studies
Evaluate how mRNA formulations behave in vivo, gaining a detailed understanding of their tissue distribution and pharmacokinetic profiles.
In Vivo Reporter mRNA Evaluation
Assess the organ-specific delivery performance of diverse LNP formulations using various reporter mRNA constructs (e.g., FLuc, Cre recombinase).
Whole Organ Bioluminescence Imaging
Visualize and quantify reporter mRNA expression in bulk tissues with bioluminescence imaging, providing an organ-level readout of mRNA expression.
Organ Histopathology
Analyze tissue samples for detailed cellular insights into the safety and tolerability of administered mRNA formulations.
Why Choose Our Platform?
End-to-End Project Support
From initial mRNA design all the way to in vivo preclinical evaluation, we offer comprehensive and seamless support across your entire project lifecycle.
Accelerated Project Execution
Save time and resources by leveraging our established platform capabilities—no need to secure your own research infrastructure or ethics approvals.
Specialized mRNA Expertise
Leverage our extensive portfolio of mRNA expertise gained from >3 years of supporting mRNA-focused preclinical research projects across various therapeutic domains.
Partner With Us
Our mRNA platforms are designed to remove logistical barriers and deliver fruitful scientific outcomes for preclinical research teams across the entire project workflow. By partnering with us, you can focus on advancing your mRNA vaccine or therapeutic development program with confidence.
Contact us today to discuss how our In Vivo Pharmacology platform can support your next preclinical study.
Examples
Ex vivo imaging of (a) firefly luciferase (FLuc) expression and (b) LNP biodistribution in major peripheral organs (liver, kidneys, spleen, lungs and heart) of C57BL/6J mice 24 h after intravenous injection of PBS or immune cell-targeted mRNA-LNPs.
Get in touch.
Email us at help@messenger.bio or fill out the form below, and we will get back to you within 48 hours.