Custom mRNA

High-throughput, on-demand mRNA & LNP biomanufacturing for preclinical discovery

At Messenger Bio, we specialize in the production of high quality mRNA for a variety of research applications. We also provide cutting-edge mRNA-lipid nanoparticle (mRNA-LNP) formulation services that build upon our own internal drug delivery research expertise. All production takes place in Melbourne, Australia by a team of dedicated scientists.

We have served customers across academia and industry in 14 countries (and counting).

It would be our honor to serve you, too.

Our RNA production workflow

Our mRNA Services

‣ Free consultation to provide experimental design advice

‣ Coding sequence optimization using our proprietary mRNA design algorithm (our algorithm employs a different design strategy to the standard, commercially available codon optimization tools)

‣ Optimization of untranslated regions (UTRs) for in vitro and in vivo stability and expression

‣ 5’ Cap1 capping (superior to Cap0)

‣ Access to various modified nucleotides for improved translation and reduced immunogenicity (e.g., N1-methylpseudouridine, 5-methoxyuridine)

‣ Flexible production scales that are suited to preclinical research (µg to mg)

‣ Robust purification methods that remove dsRNA (double stranded RNA) contaminants as well as other leftover reaction components (typical purification methods fail to remove dsRNA contaminants, resulting in strong immunogenicity and reduced protein expression)

‣ A wide range of tagging/labelling options for tracking mRNA localization or reporting on protein expression (e.g., Cy5-labeled mRNA, fluorescent reporter-tagged mRNA).

‣ Robust mRNA QC testing (purity, integrity, concentration, etc.)

We have successfully delivered on a wide range of research projects, from mRNA vaccine discovery to mRNA-encoded genome editing. We honor the privacy of each customer, while applying the learnings from each project to continuously refine our product and service offerings for future customers.

If you are thinking about using mRNA in your research, we have a portfolio of expertise that will maximize your chances of experimental success. Let us handle your mRNA design and production so that you can focus on what you do best.

Have a specific project in mind?

Not sure where to start?

Alternatively, email us at hello@messenger.bio and we will get back to you within 48 hours.